NovaSeq X系列
将先进的化学、光学和信息学技术相结合，实现了超凡的速度和数据质量、出色的通量和可扩展性。
Infinium Custom Methylation Kit包含Infinium HTS iSelect Methyl Custom BeadChip plus试剂，使研究人员和商业用户能够为关键的表观遗传学研究应用开发突破性的检测方法。
Infinium Custom Methylation Kit
Fully customizable methylation microarray for large, targeted epigenetic applications.
每张芯片24个样本
样本数量
Overview
High-throughput workflow
The Infinium HTS iSelect Methyl Custom BeadChip is offered in a 24-sample format with updated Infinium automation protocols and an automated workflow for bisulfite conversion. These features improve workflow efficiency, decrease sample processing costs, and allow users to scale their operations up to hundreds of thousands of samples per year.
High-throughput workflow
The Infinium HTS iSelect Methyl Custom BeadChip is offered in a 24-sample format with updated Infinium automation protocols and an automated workflow for bisulfite conversion. These features improve workflow efficiency, decrease sample processing costs, and allow users to scale their operations up to hundreds of thousands of samples per year.
High-throughput workflow
The Infinium HTS iSelect Methyl Custom BeadChip is offered in a 24-sample format with updated Infinium automation protocols and an automated workflow for bisulfite conversion. These features improve workflow efficiency, decrease sample processing costs, and allow users to scale their operations up to hundreds of thousands of samples per year.
Key features of the Infinium Custom Methylation Kit
规格
Required Products
Requires purchase of the Infinium HTS iSelect Methyl Custom BeadChip-24 kit. Each kit contains 2 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 48 DNA samples.
Requires an iScan Sequencing System.
Optional introductory course for 3 days of hands-on instruction covering all essential steps in the Infinium protocol, including sample and BeadChip preparation, sample scanning, and primary data evaluation and analysis using array analysis software is available for purchase.
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结果
Applications
The Infinium Custom Methylation Kit allows users to create custom high-throughput assays to measure DNA methylation in targeted regions of the genome for commercial and academic epigenetic applications, including common disease research, cancer research, epigenetic aging, and nutriepigenomics.
Example workflow
Method
甲基化芯片能在单核苷酸水平上对整个基因组的甲基化位点进行高通量的定量检测。
Scan
iScan芯片扫描仪支持高通量的BeadChip处理，可快速准确地扫描成百上千个样本。
Analyze
GenomeStudio数据分析软件可对Illumina芯片平台生成的数据进行可视化与分析。
Related applications and methods
Large-scale genotyping with microarrays can identify variants associated with disease risk in large cohorts or populations.
Documentation
产品资料
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Selection tools
Library Prep & Array Kit Selector
寻找符合您需求的测序文库制备试剂盒或芯片。按方法、种类等筛选。比较、分享和订购试剂盒。
针对您感兴趣的基因，帮助您找到适合的测序panel和芯片。
DesignStudio Custom Assay Design Tool
DesignStudio是一款基于网络的检测设计工具，可帮助研究人员设计和订购定制基因分型芯片探针或定制测序检测。
Figures
Infinium I and II assays allow for broader coverage of CpG sites
Illumina methylation BeadChips employ both Infinium I and Infinium II assays, enhancing the overall breadth of coverage. (A) Infinium I probe designs use 2 bead types per CpG locus, 1 each for the methylated and unmethylated states. (B) Infinium II probe designs use 1 bead type for both states.
Design and manufacturing process
Researchers work with Illumina technical design and customer service teams to refine the BeadChip marker content and coordinate the ordering and production process.
- Zhou L, Ng HK, Drautz-Moses DI, et al. Systematic evaluation of library preparation methods and sequencing platforms for high-throughput whole genome bisulfite sequencing. Sci Rep. 2019;9(1):10383. Published 2019 Jul 17. doi:10.1038/s41598-019- 46875-5
Resources
Discover the Flexible, Scalable Infinium Workflow
Infinium Methyl Custom-24 Kit (48 Spl)
20042146
Infinium HTS iSelect Methyl Custom Beadchip，48个样本
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Infinium® Assay: 客户现场实践培训
20015273
在客户现场提供为期三天的实践指导，帮助用户熟悉Infinium实验方案的基本步骤。本课程提供了有关样本和BeadChip制备、使用iScan系统进行样本扫描以及使用芯片分析软件进行原始数据评估和分析的实践培训。
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FAQs
The Infinium HTS iSelect Custom BeadChip includes the standard SNP controls available on the Methylation EPIC BeadChip.
The GenomeStudio Methylation Module extracts beta values and provides sample clustering analysis for Infinium HTS iSelect Methyl Custom BeadChip data. The BeadArray Controls Reporter software tool is not supported at this time.
Notably, there are many freeware applications in Bioconductor, such as SeSAMe, that provide enhanced normalization and visualization options. Illumina does not support these freeware solutions directly.
No, Illumina LIMS does not support Infinium HTS iSelect Methyl Custom BeadChips at this time.
No, FFPE samples are not currently supported.
The Zymo Research EZ-96 Methylation-Lightning MagPrep Kit in manual and automated formats is supported for use upstream to Infinium Methylation assays. Review results in this technical note for more details.
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结果
MiSeq v3试剂盒
与早期版本相比，优化的试剂盒可增加簇密度和读长，从而提高测序质量分值。
TruSight Oncology 500
使用涵盖所有主要变异类别以及来自FFPE组织的基因特征（TMB、MSI和HRD）的大型泛癌panel实现CGP。
Illumina DNA Prep
快速、集成的文库制备工作流程，适用于各种测序应用。
Infinium MethylationEPIC v2.0 Kit
可靠的甲基化分析芯片，广泛覆盖CpG岛、基因和增强子，用于全表观基因组关联研究。
Infinium Mouse Methylation BeadChip
在整个甲基化组中具有超过285,000个标记，用于对多种小鼠品系进行高分辨率表观遗传学分析。
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